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A group × time interaction indicated a difference in the 6-month evolution of white matter integrity (as measured by generalized fractional anisotropy, gFA) in favor of the NAC group, which showed an 11% increase

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Significant between-study heterogeneity ( I 2 = 70·9 %, P = 0·002) was reduced by subgrouping by study location, treatment duration and type of control (Table 2)