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Notably, the hippocampus of such mutant mice showed significant abnormalities in synaptic development: an increased proportion of immature synapses, downregulation of the expression of the presynaptic membrane marker protein SNAP‐25, and a reduced number of synaptic vesicles, accompanied by impaired long/short‐term synaptic plasticity [85]

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The literature search and screening flowchart is shown in Figure 1