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In patients with T2-high severe asthma, an elevated 15LO1/PEBP1 ratio and elevated LC3-II protein level was associated with low mitochondrial DNA in bronchoalveolar lavage fluid, suggesting that asthmatic epithelial cells in vivo reside in a “pre-ferroptotic,” metabolically stressed state that actively engages autophagy to prevent release of pro-inflammatory mediators and maintain homeostasis

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Biodiversity 2021, 18, e2100043 10.1002/cbdv.202100043