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In a 2020 publication by Eduardo Nunes Chini, M.D., Ph.D., the Mayo Clinic scientist said, “Whether oral administration of NR or NMN is indeed superior to nicotinamide or niacin in vivo has not been systematically approached, and such studies are urgently needed.” In other words, the effects of NMN compared to nicotinic acid or niacin have not been thoroughly tested in living organisms

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In off-label veterinary use, most dogs tolerate it well