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Acknowledgements This work was supported by the National Institutes of Health (NIH) grants P01CA066996 and R35CA253125 (to B.L.E.), R01CA262188 and R01CA2144608 (to E.S.F.) and R01CA218278 (to N.S.G

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9 Department of Pediatrics, Division of Metabolism and Children’s Research Center, University Children’s Hospital Zurich, Zurich, Switzerland