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SESN2 interact with Unc-51-like protein kinase 1 (ULK1) to promote Beclin1 phosphorylation, Parkin mitochondrial translocation, and further facilitate mitophagy ( via modulating the recruitment of autophagosome-associated protein MAP1LC3B (LC3B) ( via binding to ATPase catalytic subunit in neuronal cells, and alleviate neurodegenerative diseases ( via activating autophagy, and alleviated NIHL in adult CBA/J mice ( 4 NLRP3 inflammasome in hearing loss Inflammasomes are likely responsible for elevated ROS production in immune cells

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