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Long-Term Disease Course of Crohn's Disease in a Prospective European Population-Based Inception Cohort: An Epi-IBD Cohort Study - Clinical Gastroenterology and Hepatology

Thus, the imbalance between antioxidant defense and free radical growth creates a favorable environment for oxidative damage, inflammation, and fibrosis in hepatocytes, promoting lipid peroxidation of cell membranes, apoptosis, and ROS-mediated somatic mutations of nuclear and mtDNA

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Dihydrocaffeic acid (0.15 μM-2.0 mM) shows antiproliferative activity against human U937 cells, with IC 50 of 212.7 μM [3]