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47 The TNFR1-RIP-TRADD-TRAF2 complex plays a crucial role in regulating cell survival and apoptosis 48 ,49 , and when TNFR1-mediated signaling successfully activates the complex and NF-κB signaling, the cells will survive in the presence of FLICE inhibitory proteins (FLIP, Caspase-8 inhibitor), and conversely lead to cell death

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Autophagy can inhibit apoptosis by eliminating damaged mitochondria, yet excessive autophagy may also induce apoptosis [7]