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To receive achievement points for IA-2, we proposed at §§ 512.735(c)(2)(i) and (ii) that the ASM participant must enter into at least one CCA with a primary care practice that includes at least three of the following five following collaborative elements: data sharing, co-management, transitions in care planning, closed-loop connections, and care coordination integration as proposed at §§ 512.735(c)(2)(ii)(A) through (E)

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Treatment reduced intracellular 1-MNA, raised intracellular NAD + and SAM, and suppressed lipid accumulation during differentiation