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Sodium benzoate treatment linked to increased glutathione levels and improved positive and negative symptoms, global function, and quality of life in patients with clozapine-resistant schizophrenia: secondary analysis of a randomized clinical trial
Activated BDNF-TrkB signaling leads to stimulation of the Akt/mTOR pathway, causing activation of the WNT/β-catenin pathway and enhancing synaptic proteins 134
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Therefore, the best metabolomic practices are essential to overcome this initial phase, for instance, conducting studies that involve large numbers of subjects, assessment of environmental influences on breath samples, implementation of reproducible and transparent data preprocessing workflows and performing a robust data analysis, among others 29,33