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In metabolic tissues, especially adipose tissue, macrophage-derived ROS, advanced glycation end-products (AGEs), which are proteins or lipids that undergo glycation when exposed to sugars, leading to the formation of potentially harmful end-products, interact with the receptor for advanced glycation end-products (RAGE), and insulin resistance-induced mitochondrial overload in β-cells drive systemic oxidative stress and dyslipidemia, contributing to endothelial dysfunction and atherosclerosis (66–69)
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Figure 5: Low B12 levels in the blood can affect cell and DNA production, mess with energy and hormone balance, and cause proteins to thicken the blood