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[DOI] [PMC free article] [PubMed] [Google Scholar] 462.Huang Y., Zhang J., You H., Ye F., Yang Y., Zhu C., Jiang Y.C., Tang Z.X

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The disruption of the ER and induction of the unfolded protein response (UPR) by SARS-CoV-2 has been described by several authors ( ER 2+ concentration and increase in Ca i 2+ (290, 291) and one of the mechanisms generating it is a direct interaction between E-protein and SERCA2b pump resulting in a decrease in SERCA-mediated ER Ca 2+ reloading ( 2+ gradient across the ER membrane (292)