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Circulating TMAO activates the NLRP3 inflammasome and the NF-κB signaling pathway in alveolar macrophages, promoting the release of IL-1β/IL-18 and triggering pyroptosis, ultimately exacerbating the damage to the pulmonary vascular endothelial barrier (151)

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[DOI] [PMC free article] [PubMed] [Google Scholar] Chabattula S