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Others develop a reaction the size of a baseball, warm to the touch and slightly raised above the surrounding skin
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They are defined by impairments in communication and social interaction along with restrictive and repetitive behaviors ( Autism spectrum disorder has been recently estimated to affect 1 out of 68 individuals in the United States ( A great majority of ASD research has concentrated on genetic causes of ASD ( de novo mutations, thereby pointing to acquired mutations and/or mutations secondary to errors in DNA maintenance rather than inherited genetic syndromes ( Recent studies have suggested that ASD is associated with impairments in basic physiological processes such as redox (37, 38), Angelman syndrome (39), Septo-optic dysplasia (40), and Down syndrome (41, 42)
