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In the endoplasmic reticulum, PLOOH starts the PERK–eIF2α–ATF4–CHOP pathway and suppresses NRF2 signals, further ruining the redox balance ( 2.3 Experimental and clinical evidence The current research evidence covers many levels such as cellular models, animal studies, and clinical samples, suggesting that ferroptosis plays an important pathogenic role in kidney injury associated with DKD