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To demonstrate that suppression of p70S6K protein and pNPM1 by RSL3 is GPX4 inhibition-specific in PTC cells, we treated K1 cells with RSL3 (3 µM) in the presence of ferrostatin-1 (5 µM), an effective inhibitor of ferroptosis and analyzed by Western blotting

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The role of renal hypoxia in the pathogenesis of diabetic kidney disease: a promising target for newer renoprotective agents including SGLT2 inhibitors