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When intended only to cover and protect a wound, to absorb exudate, and to maintain appropriate moisture balance within the wound and otherwise meeting the device definition, generally the FDA's Center for Devices and Radiological Health (CDRH) regulates wound dressings composed of natural biomaterials, including animal and human derived tissue as devices, and they are currently subject to 510(k) requirements

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Studies have shown that BBR could inhibit oxidative stress and ameliorate kidney damage (Zhao et al., 2023), pancreatic dysfunction (Xu et al., 2021a)