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Administration of local and intraperitoneal carnosine has been shown to enhance wound healing and promote granulation, increase tensile strength, collagen deposition and hyroxyproline content in the wound area in diabetic mice [135]

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GCS is a mitochondrial-localized four-enzyme complex that decarboxylates glycine to form CO 2 and deaminates the remaining carbon to form mitochondrial 5,10-methylene-THF (Kikuchi et al., 2008)