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ATF4 also plays a pro-tumorigenic role in aggressive subtypes of acute myeloid leukemia (AML), in part through transcriptional activation of the SSP enzymes
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Another study that compared White (Caucasian) and Black (African-american) skin also found that the Caucasian subjects who had fairer skin were susceptible to more than twice the amount of UVA and UVB rays penetrating the skin compared to their African-american counterparts with darker skin 13 This protective effect of melanin/pigmentation is also supported by the inverse relationship of skin pigmentation and the likelihood of sun-induced skin cancers 14 – subjects with White skin are almost 70 times more likely to develop skin cancer than subjects with Black skin 15
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