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The wide variation in extracellular (e.g., 2–20 µmol/L in plasma) and intracellular (0.5–10 mM) GSH concentrations in animal cells [15] led to the notion that this leads to a large difference in reducing potential between the intracellular and extracellular compartments that could be exploited for triggered intracellular delivery of several bioactive molecules [77]