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33 GUT MICROBE-PRODUCED IMIDAZOLE PROPIONATE AGGRAVATED HEPATIC FIBROSIS BY BOOSTING HEPATOCELLULAR DEATH AND M1 MACROPHAGE POLARIZATION Zhu Qin 1,2,3 , Fangyuan Chen 1,2,3 , Jian Wu 2,3,4 and Wei Jiang 1,2,3 , (1)Department of Gastroenterology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen 361015, China, (2)Fudan University, Department of Gastroenterology and Hepatology, Zhongshan Hospital, Shanghai, China, (3)Shanghai Institute of Liver Diseases, Fudan University Shanghai Medical College, Shanghai 200032, China, (4)Dept