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Moreover, coating T cell membranes that highly express PD-1 on the surface of PLGA@MnO 2 nanoparticles loaded with the STING activator 2’3’-cGAMP (PSMP), this nanodrug effectively disrupts the pre-metastatic niche (PMN) by blocking high PD-L1 expression on MDSCs and activating the STING signaling pathway thereby inhibiting metastasis (137)

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It may also be preferable when the goal is steady-state hormone elevation rather than acute pulsatile release

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