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Ascorbic acid can also shift oxidation states of these minerals inside the body, and this can remove copper from ceruloplasmin and help deliver it to cells, but can interact with overloaded iron by making it more likely to cause oxidative stress
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Nicotinamide adenine dinucleotide phosphate oxidase (NOX) isoforms are major sources for endogenous ROS, multifarious NOX isoforms are localized to various cellular membranes and involved in many physiological or pathological events (37), dihydroorotate dehydrogenase (DHOH) (38), mitochondrial glycerol-1-phosphate dehydrogenase (mGPDH) (39), cytochrome b5 reductase (40), monoamine oxidases (MAOs) (41), aconitase (ACO) (42), xanthine oxidoreductase (XOR) (43), alpha-Ketoglutarate dehydrogenase complex (KGDHC) (44), and so on
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