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In the LUCENT 1 trial, moderate-to-severe UC patients were randomized in a 3:1 fashion to receive either IV mirikizumab 300 mg or placebo every 4 weeks for 12 weeks

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The absolute bioavailability following intramuscular injection was found to be approximately 14–19% in rats and 45–51% in beagle dogs, indicating variable absorption depending on the species and administration route