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Gamma glutamyl transferase is found in hepatocytes and in biliary epithelial cells. Elevation typically indicates cholestasis or, when alkaline phosphatase is normal, induction of hepatic metabolic enzymes, often in response to long

Since the NO/PGI 2 -independent vasodilatation originally described was co-incident with vascular smooth muscle hyperpolarization, and was abolished by depolarizing concentrations of potassium, it was proposed to be mediated by an “EDHF”

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