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Paraxanthine behaves as a stronger psychostimulant than caffeine in rats Paraxanthine produces stronger motor-activating effects than caffeine This depends on its selective ability to inhibit cGMP-preferring PDE Paraxanthine produces dopamine release in the dorsal striatum This profile of paraxanthine might contribute to the reinforcing effects of caffeine Acknowledgments Supported by fundings from NIDA Intramural Research Program Footnotes Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication

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HeitmannHAndlauerTFMKornTMühlauMHenningsenPHemmerBet al