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The latest members associated with the CRH family are four teneurins, or teneurin C-terminal associated peptides (TACPs), which share homology with the amino acid sequence of CRH and bind to latrophilins (a group of highly conserved GPCRs)

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Rather than acting broadly across the microbiome, it lives within the mucus layer itself, and early research suggests this is how it helps reinforce the gut barrier and support the body's everyday response to stressors

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