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showed that retroviral vectors can deliver transgenes into spermatogonial stem cells in vitro and showed that transfer of such transgenic stem cells into the testes of mice in which their own spermatogonial stem cells had been depleted resulted in repopulation of testes and donor cells.” The transgene is subsequently integrated into the chromosomes of the offspring (196)
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This is crucial to achieving optimized therapeutic efficacy and minimizing potential side effects
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