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Cellular metabolic states dictate mitochondrial size, shape, function, and positioning

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The mitochondrion, contains its own DNA (mDNA) which is replicated independently of the host genome, mDNA comprises a circular genome of 16, 569 base pairs and encodes 37 genes, including 13 subunits of the electron transport chain (ETC), 2 ribosomal RNAs and 22 tRNAs, the remaining mitochondrial proteins are encoded by the nuclear genome and are imported into the mitochondria (66)