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When used in combination with a vascular disrupting agent (CA4-NPs) to boost tumor fibrin deposition and intensify hypoxia, this nanodrug achieved remarkable efficacy: a 98.1% inhibition rate in CT26 tumor models (initial volume ~480 mm³) and complete eradication of tumors in 4 out of 6 treated subjects after a single dose (288)
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10.1016/j.ccr.2013.10.025 [DOI] [PMC free article] [PubMed] [Google Scholar] 58.Probst BL, McCauley L, Trevino I, Wigley WC, Ferguson DA
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