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Additionally, metformin inhibits complex I-dependent respiration and mitochondrial glycerophosphate dehydrogenase (mGPDH) and activates sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3), making it directly involved in oxidative stress modulation ( Furthermore, it is important to note that the effectiveness of metformin varies depending on the specific tissue and the dosage used (Kefas et al., 2004
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※ For those aiming for intensive brightening results, once per week is advised
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