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How to Treat Ulcerative Colitis and Crohn’s Disease For both Crohn’s and colitis, the first-line of conventional treatment with a gastroenterologist tends to focus on: Decreasing inflammation such as with oral mesalamine for Crohn’s and sulfasalazine and 5-aminosalicylates in colitis Using immunosuppressants (biologics) such as Remicade (infliximab) and Humeria (adalimumab) for both conditions While many treatment options focus on reducing inflammation for symptom relief, it is also important to determine the root cause of the chronic inflammation