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Exogenous sources for ROS/RNS include tobacco, water and air pollution, alcohol, drugs, heavy metals (eg, gentamicin, tacrolimus, cyclosporine, bleomycin, doxorubicin, morphine, diazinon, potassium bromate, ethanol, acrylamide, arsenic, and bisphenol A), radiation, industrial solvents, and cooking (4)