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Furthermore, cluster analyses revealed that the dominant genera with their co-occurring highly abundant microbes influence more macro-molecular functions (e.g., energy production pathways), and the less abundant microbial species detected in all three clusters supported the dominant genera through their involvement in more specialized functions (e.g., archaeon Methanobrevibacter , hydrogen producer and methanogen, and Desulfovibrio , a sulfate reducer) (Arumugam et al., 2011
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Changes in adhesion molecule-1 (sICAM-1) in serum, white blood cell (WBC), 11 dehydrothromboxane B2 (11-DTX-B2), and 8-epi-prostaglandin F2 alpha (8-epi-PGF2α) have been reported as associated with smoking-related diseases such as cardiovascular diseases