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Since the first CHO GEM reconstruction 23 , various FBA-based approaches have guided rational cell line engineering 4 , optimized culture processes 24 , and also supported systematic media reformulation by integrating multivariate data analysis (MVDA) 25,26

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(2) articles not written in English, conference abstracts only, review articles, duplicated papers, or papers that do not relate to BP, MDD, or SZ were excluded