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The honest clinical picture is cautious: DSIP is investigational and research-only , much of the existing human data is older, limited, and inconsistent , and the available trials point in conflicting directions

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OU749 is an uncompetitive inhibitor with a K i of 17 uM [76], while GGsTop is a mechanism-based irreversible inhibitor, with an active ester of phosphonate mimicking the transition state of GSH in the GGT pocket, whose k inact /K I is 57 M −1 •s −1 [77]