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The metabolism of GSH is closely connected to Meister’s γ-glutamyl cycle, in which a pivotal role is played by membrane GGT enzyme.5 This enzyme participates in the Salvage pathway of extracellular GSH by catalyzing its hydrolysis to amino acid components of cysteine, which is used for intracellular GSH biosynthesis.6 Normally, due to cysteine toxicity, the physiological level of this amino acid in cells is very low, and in plasma cysteine occurs mainly in the form of a disulfide-cystine

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Subsequent investigations unveiled that cell death orchestrated by 3Cpro was proficiently obviated by ferroptosis inhibitors [708]