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Solid-phase extraction-electrospray ionization mass spectrometry for the quantification of folate in human plasma or serum

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In the extracellular space, the rate of H 2 O 2 elimination by 1,000 µM pyruvate (95%, 21–25 min) is rapid, considering minimal peroxidase activities present in this compartment and a 100- to 500-fold higher H 2 O 2 concentration in plasma compared to the intracellular environment