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RAGE-induced Cytosolic ROS Promote Mitochondrial Superoxide Generation in Diabetes

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Weight Loss In SUSTAIN 1 and PIONEER 1 trials, with patients managing early-stage diabetes with diet and exercise alone, subcutaneous semaglutide 1.0 mg led to a mean weight reduction of 4.5 kg, whereas oral semaglutide 14 mg achieved a 3.7 kg reduction [28]