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We also performed sex-stratified meta-analyses restricted to males and females, and leave-one-cohort-out analyses for each of the 11 constituent cohorts, with both multi-ancestry (leaving out all ancestries from that cohort, if the cohort had multiple) and European-only versions

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For a 10 mg retatrutide vial: Add 2 mL of BAC water = 5 mg/mL concentration (each 10 units on a U-100 syringe = 0.5 mg) Add 3 mL of BAC water = 3.33 mg/mL concentration (each 10 units = 0.33 mg) Add 1 mL of BAC water = 10 mg/mL concentration (each 10 units = 1 mg) Most researchers prefer the 2 mL reconstitution because it provides a convenient concentration that aligns well with common titration steps