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Novo Nordisk built an entire phase 3 program, branded CagriSema, around the idea of bolting an amylin analog onto a GLP-1 agonist
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On one hand, mitochondrial Ca 2 + uptake is mainly regulated by voltage-dependent anion channels (VDAC) on the outer mitochondrial membrane and the mitochondrial calcium uniporter (MCU) complex on the inner mitochondrial membrane
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