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deacetylation of PGC-1α → mitochondrial biogenesis SIRT3 (mitochondrial): deacetylation of mitochondrial enzymes → better OXPHOS efficiency SIRT6 : stabilization of telomeres, DNA repairs SIRT2 : regulation of metabolism and the cell cycle Sirtuin activation is the main longevity mechanism associated with NAD+

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Similar results were found in naturally aged mice 35

Apply a moderate amount to concerned areas after basic skin care routine