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It is noteworthy that GPX3 loss was not associated with increased ROS levels or DNA damage, however exposure to carcinogens resulted in an increase in M2 macrophages, elevated proinflammatory mediators and increased DNA damage in tumor cells

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Although the glutathione pool of mitochondria is less than 20% of the total cell GSH, its role in the organelle is crucial to the maintenance of cell homeostasis and to routing disabled cells into apoptotic or necrotic death