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Intranasal treatment with nanoparticles containing thyrotropin-releasing hormone significantly reduced the seizure afterdischarge duration and increased the number of stimulations required to reach a generalized tonic–clonic seizure in a kindling model of temporal lobe epilepsy [250]

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Persistent inflammation driven by cytokines like IL-1β, TNF-α, and IL-6 plays a crucial role in the initiation and pathogenesis of lumbar disc degeneration