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Some reports indicate that, in a functional p53 background, HO-1 has an anti-tumoral role through the induction of cell cycle arrest and apoptosis [96], while others suggest that HO-1 promotes tumor progression and metastasis by reducing the expression of intercellular adhesion molecule 1 (ICAM-1) and CXCL10 and consequently decreasing T cell-mediated cytotoxicity against CRC cells [97]