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Individuals pursuing metabolic optimization or longevity care with emphasis on sleep, cognition, and tissue repair.6,7 How Sermorelin Supports Muscle Preservation in GLP-1 Users GLP-1 receptor agonists such as semaglutide can reduce muscle mass by lowering appetite, caloric intake, and indirectly decreasing anabolic signaling through the GH–IGF-1 axis.8 Sermorelin counteracts this by restoring physiologic GH pulses and helping to improve protein synthesis , muscle recovery , and insulin sensitivity

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doi: 10.18632/aging.100544