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Although this central mechanism probably forms the basis of 2-AG involvement in memory, pain, anxiety, mood, stress, regulation of hyperexcitability, neuroprotection, or addiction, its peripheral interactions with both CB1 and CB2 receptors also revealed its role in regulating the energetic metabolism of the liver, muscle, or adipose tissue, intestinal function, cell proliferation, immune defenses, bone development, or inflammation

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Independent groups have characterised the compound across overlapping research model systems, providing cross-laboratory replication for the core observations documented in the foundational papers