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In addition to its peripheral effect, diclofenac and other nonsteroidal antiinflammatory analgesics may have a contraceptive effect (analgesic) in the central nervous system acting on the release of prostaglandins and / or through the neuronal systems which use and catecholamines neurotransmitter serotonin (Pain, 1994, 57: 197-205)

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This can be explained by the fact, that superoxide radical is necessary to achieve redox cycling of metal ions (Halliwell and Gutteridge 1990)