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Abbreviations AD: Alzheimer's diseases CI: Confidence interval GR: Glutathione reductase GSH: Glutathione reduced form GSSG: Glutathione disulfide oxidized form GSTs: Glutathione transferases Hb: Hemoglobin HOE: Human oral epithelium HPLC: High-performance liquid chromatography I: Irritant classification JNK: Jun kinase MTT: Methylthiazolyldiphenyl-tetrazolium bromide NADPH: β -Nicotinamide adenine dinucleotide phosphate NEM: N-ethylmaleimide NI: Nonirritant classification OS: Oxidative stress PD: Parkinson's disease RDI: Recommended dietary intake RHE: Reconstructed Human Epithelium ROS: Reactive oxygen species SD: Standard deviation of the mean WMA: Assembly of the World Medical Association