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Those preliminary findings were later corroborated by several studies by us or other researchers that showed that: (a) Single and 24hour TNFα and IL6 plasma levels are elevated in adults and children with sleep apnea independently of obesity (103, 118,154-158) (Figure 10); (b) body mass index (BMI) positively correlates with both TNFα and IL6 levels, suggesting that these two cytokines may play a role in daytime sleepiness experienced by obese individuals in the absence of sleep apnea (25); (c) daytime levels of IL6 and TNFα are elevated in healthy humans experiencing somnolence and fatigue as a result of total sleep deprivation (137) or even after a modest sleep loss by restricting sleep to 6 hours a night per week (76,159); and (d) a midafternoon nap following a night of total sleep deprivation is beneficial for both the suppression of IL6 secretion and for the improvement of alertness (83)